John August, the acclaimed screenwriter of GO, BIG FISH, CHARLIE AND THE CHOCOLATE FACTORY and THE CORPSE BRIDE, makes his directorial debut with THE NINES, an intricately constructed intriguing blur of reality, virtual reality and metaphysical fantasy. The film unfolds in three parts, featuring the same actors in different (and in some ways overlapping) incarnations. (Source)
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It feels like the trailer wants us to believe that the main characters are part of game like The Sims or Second Life and what one character tries to do to break free of it.